Listeria monocytogenes is a foodborne pathogen capable of causing severe invasive infections, particularly in vulnerable populations such as neonates, pregnant women, the elderly, and immunocompromised individuals. While initial symptoms may resemble mild gastrointestinal illness, the pathogen can cross the blood-brain barrier, leading to serious neurological complications, including meningitis, encephalitis, and rhombencephalitis. Neurolisteriosis is often characterised by altered mental status, seizures, and focal neurological deficits. Diagnosis requires a high index of suspicion, supported by cerebrospinal fluid analysis and blood cultures. Prompt initiation of targeted antibiotic therapy, typically with Ampicillin or Penicillin, is critical for improving outcomes. Delays in treatment can result in significant morbidity or mortality.